PKRRATING CAN BE FUN FOR ANYONE

The interfacial residues are hugely conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements reveal that the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations assist a model wherever activating RNA serves as being a scaffold to bind a number of PKR monomers, raisi

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